Welcome to the Interactive Section of the site. Here we will be posting papers and other replication news. Please feel free to add your comments to any of the postings here.

Publication Alert

Replication fork stalling by bulky DNA damage: localization at active origins and checkpoint modulation

Eugen C. Minca and David Kowalski

Nucl. Acids Res. (2011) 39 (7): 2610-2623.
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Publication Alert

Sld2 binds to origin single-stranded DNA and stimulates DNA annealing

Diane M. Kanter and Daniel L. Kaplan

Nucl. Acids Res. (2011) 39 (7): 2580-2592.
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Publication Alert

Pre-replication complex proteins assemble at regions of low nucleosome occupancy within the Chinese hamster dihydrofolate reductase initiation zone

Yoav Lubelsky, Takayo Sasaki, Marjorie A. Kuipers, Isabelle Lucas, Michelle M. Le Beau, Sandra Carignon, Michelle Debatisse, Joseph A. Prinz, Jonathan H. Dennis, and David M. Gilbert

Nucl. Acids Res. 2011 39: 3141-3155
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Publication Alert

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

Susan E. Tsutakawa, Scott Classen, Brian R. Chapados, Andrew S. Arvai, L. David Finger, Grant Guenther, Christopher G. Tomlinson, Peter Thompson, Altaf H. Sarker, Binghui Shen, Priscilla K. Cooper, Jane A. Grasby, John A. Tainer

Cell, Volume 145, Issue 2, 198-211, 15 April 2011
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Publication Alert

GINS and Sld3 Compete with One Another for Mcm2-7 and Cdc45 Binding

Irina Bruck and Daniel L. Kaplan

J. Biol. Chem. 2011 286: 14157-14167.
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Publication Alert

Replication-Fork Stalling and Processing at a Single Psoralen Interstrand Crosslink in Xenopus Egg Extracts

Cyrille Le Breton, Magali Hennion, Paola B. Arimondo, Olivier Hyrien

PLoS ONE 6(4): e18554.
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Publication Alert

Crystal structure of the C-terminal domain of human DNA primase large subunit: Implications for the mechanism of the primase-polymerase α switch

Vinod B. Agarkar, Nigar D. Babayeva, Youri I. Pavlov and Tahir H. Tahirov

Cell cycle Volume 10, Issue 6 March 15, 2011 Pages 926 - 931
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Publication Alert

Subtle interactions between heterochromatin and DNA replication timing

Joel A. Huberman

Cell cycle Volume 10, Issue 6 March 15, 2011 Pages 873 - 878
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Publication Alert

Inter-origin cooperativity of geminin action establishes an all-or-none switch for replication origin licensing

Koji L. Ode, Koichi Fujimoto, Yumiko Kubota, Haruhiko Takisawa

Genes to Cells Volume 16, Issue 4, pages 380–396, April 2011
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Publication Alert

The structural basis for MCM2–7 helicase activation by GINS and Cdc45

Alessandro Costa, Ivar Ilves, Nele Tamberg, Tatjana Petojevic, Eva Nogales, Michael R Botchan & James M Berger

Nature Structural & Molecular Biology 18, 471–477 (2011)
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Publication Alert

Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome

Duane L Guernsey, Makoto Matsuoka, Haiyan Jiang, Susan Evans, Christine Macgillivray, Mathew Nightingale, Scott Perry, Meghan Ferguson, Marissa LeBlanc, Jean Paquette, Lysanne Patry, Andrea L Rideout, Aidan Thomas, Andrew Orr, Chris R McMaster, Jacques L Michaud, Cheri Deal, Sylvie Langlois, Duane W Superneau, Sandhya Parkash, Mark Ludman, David L Skidmore & Mark E Samuels

Nature Genetics 43, 360–364 (2011)
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Publication Alert

Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome

Louise S Bicknell, Sarah Walker, Anna Klingseisen, Tom Stiff, Andrea Leitch, Claudia Kerzendorfer, Carol-Anne Martin, Patricia Yeyati, Nouriya Al Sanna, Michael Bober, Diana Johnson, Carol Wise, Andrew P Jackson, Mark O'Driscoll & Penny A Jeggo

Nature Genetics 43, 350–355 (2011)
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Publication Alert

Mapping the FEN1 interaction domain with hTERT

Shilpa Sampathi and Weihang Chai

Biochemical and Biophysical Research Communications Volume 407, Issue 1, 1 April 2011, Pages 34-38
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Publication Alert

C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability

Jerome Korzeliusa, 1, Inge Thea, Suzan Ruijtenberga, Vincent Portegijsa, Huihong Xuc, H. Robert Horvitzb and Sander van den Heuvel

Developmental Biology Volume 350, Issue 2, 15 February 2011, Pages 358-369

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Publication Alert

RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo

Ryan J. Bourgoa, Ursula Ehmerb, Julien Sageb, and Erik S. Knudsena

MBoC Vol. 22, Issue 7, 931-939, April 1, 2011
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