Welcome to the Interactive Section of the site. Here we will be posting papers and other replication news. Please feel free to add your comments to any of the postings here.

Publication alert

The proofreading mechanism of the human leading-strand DNA polymerase ε holoenzyme Feng Wang, Qing He, Michael E. O’Donnell, and Huilin Li PNAS 122 (22) e2507232122
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Publication alert

Compact Origins and Where to Find Them: ORC's Guide to Genome-Wide Licensing get actual link when it comes out Christian Speck, Luitpold Maximilian Reuter Bioessays. 2025 May 19:e70018.
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Publication alert

Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones Jamie T. Carrington, Rosemary H. C. Wilson, Eduardo de La Vega, Sathish Thiyagarajan, Tom Barker, Leah Catchpole, Alex Durrant, Vanda Knitlhoffer, Chris Watkins, Karim Gharbi & Conrad A. Nieduszynski  Genome Biology volume 26, Article number: 122 (2025)
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Publication alert

Cryo-EM structure of apo-form human DNA polymerase δ elucidates its minimal DNA synthesis activity without PCNA Yeonoh Shin ∙ Mark Hedglin ∙ Katsuhiko S. Murakami Journal of Biological Chemistry, Volume 301, Issue 4, 108342
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A conserved phosphorylation mechanism for regulating the interaction between the CMG replicative helicase and its forked DNA substrate Sandra Koit1 ∙ Nele Tamberg ∙ Allan Reinapae ∙ Lauri Peil ∙ Arnold Kristjuhan ∙ Ivar Ilves Journal of Biological Chemistry, Volume 301, Issue 4, 108408
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Effects of CDC45 mutations on DNA replication and genome stability Milena Denkiewicz-Kruk, Deepali Chaudhry, Alina Krasilia, Malgorzata Jedrychowska, Iwona J. Fijalkowska, Michal Dmowski Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Volume 1872, Issue 5, June 2025, 119936
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Multigenerational cell tracking of DNA replication and heritable DNA damage Andreas Panagopoulos, Merula Stout, Sinan Kilic, Peter Leary, Julia Vornberger, Virginia Pasti, Antonio Galarreta, Aleksandra Lezaja, Kyra Kirschenbühler, Ralph Imhof, Hubert Rehrauer, Urs Ziegler & Matthias Altmeyer  Nature.
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Publication alert

DNA replication timing reveals genome-wide features of transcription and fragility Francisco Berkemeier, Peter R. Cook & Michael A. Boemo Nature Communications volume16, Article number: 4658 (2025)
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Publication alert

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination Derek L. Bolhuis, Dalia Fleifel, Thomas Bonacci, Xianxi Wang, Brandon L. Mouery, Jeanette Gowen Cook, Nicholas G. Brown & Michael J. Emanuele  Nature Communications volume 16, Article number: 4575 (2025
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Publication alert

The yeast CST and Polα/primase complexes act in concert to ensure proper telomere maintenance and protection Kimberly Calugaru , Eun Young Yu , Sophie Huang , Nayim González-Rodríguez , Javier Coloma , Neal F Lue Nucleic Acids Research, Volume 53, Issue 7, 24 April 2025,
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