Publication alert
04-Jun-2025 17:07
| Permalink
The proofreading mechanism of the human leading-strand DNA polymerase ε holoenzyme
Feng Wang, Qing He, Michael E. O’Donnell, and Huilin Li
PNAS 122 (22) e2507232122
Comments
Publication alert
03-Jun-2025 13:21
| Permalink
Compact Origins and Where to Find Them: ORC's Guide to Genome-Wide Licensing get actual link when it comes out
Christian Speck, Luitpold Maximilian Reuter
Bioessays. 2025 May 19:e70018.
Publication alert
03-Jun-2025 06:36
| Permalink
Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones
Jamie T. Carrington, Rosemary H. C. Wilson, Eduardo de La Vega, Sathish Thiyagarajan, Tom Barker, Leah Catchpole, Alex Durrant, Vanda Knitlhoffer, Chris Watkins, Karim Gharbi & Conrad A. Nieduszynski
Genome Biology volume 26, Article number: 122 (2025)
Publication alert
03-Jun-2025 06:36
| Permalink
Cryo-EM structure of apo-form human DNA polymerase δ elucidates its minimal DNA synthesis activity without PCNA
Yeonoh Shin ∙ Mark Hedglin ∙ Katsuhiko S. Murakami
Journal of Biological Chemistry, Volume 301, Issue 4, 108342
Publication alert
03-Jun-2025 06:35
| Permalink
A conserved phosphorylation mechanism for regulating the interaction between the CMG replicative helicase and its forked DNA substrate
Sandra Koit1 ∙ Nele Tamberg ∙ Allan Reinapae ∙ Lauri Peil ∙ Arnold Kristjuhan ∙ Ivar Ilves
Journal of Biological Chemistry, Volume 301, Issue 4, 108408
Publication alert
03-Jun-2025 06:34
| Permalink
Effects of CDC45 mutations on DNA replication and genome stability
Milena Denkiewicz-Kruk, Deepali Chaudhry, Alina Krasilia, Malgorzata Jedrychowska, Iwona J. Fijalkowska, Michal Dmowski
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Volume 1872, Issue 5, June 2025, 119936
Publication alert
03-Jun-2025 06:33
| Permalink
Multigenerational cell tracking of DNA replication and heritable DNA damage
Andreas Panagopoulos, Merula Stout, Sinan Kilic, Peter Leary, Julia Vornberger, Virginia Pasti, Antonio Galarreta, Aleksandra Lezaja, Kyra Kirschenbühler, Ralph Imhof, Hubert Rehrauer, Urs Ziegler & Matthias Altmeyer
Nature.
Publication alert
03-Jun-2025 06:32
| Permalink
DNA replication timing reveals genome-wide features of transcription and fragility
Francisco Berkemeier, Peter R. Cook & Michael A. Boemo
Nature Communications volume16, Article number: 4658 (2025)
Publication alert
03-Jun-2025 06:31
| Permalink
USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination
Derek L. Bolhuis, Dalia Fleifel, Thomas Bonacci, Xianxi Wang, Brandon L. Mouery, Jeanette Gowen Cook, Nicholas G. Brown & Michael J. Emanuele
Nature Communications volume 16, Article number: 4575 (2025
Publication alert
03-Jun-2025 06:29
| Permalink
The yeast CST and Polα/primase complexes act in concert to ensure proper telomere maintenance and protection
Kimberly Calugaru , Eun Young Yu , Sophie Huang , Nayim González-Rodríguez , Javier Coloma , Neal F Lue
Nucleic Acids Research, Volume 53, Issue 7, 24 April 2025,