tag:blogger.com,1999:blog-2706107744577821742026-09-04T17:38:38.259+01:00The Blog Site for DNAReplication.netSue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.comBlogger2290125tag:blogger.com,1999:blog-270610774457782174.post-10769912546758107292026-09-04T17:38:38.258+01:002026-09-04T17:38:38.259+01:00<b>Recent advances on mammalian DNA replication initiation and timing: From chromatin features to nuclear organization</b> Rocío Nunez-Vazquez, Geneviève Almouzni Current Opinion in Structural Biology Volume 98, June 2026, 103274 <a href="https://www.sciencedirect.com/science/article/pii/S0959440X26000564"></a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-86396221759736944542026-09-04T17:37:51.432+01:002026-09-04T17:37:51.432+01:00<b>Partitioning of parental histones between leading and lagging strands is modulated by DNA polymerase dosage </b> Quinn Dickinson , Srinivasu Karri , Odile Djom Kenmogne , Shuang Zhu , Juan Carlos Rivera-Mulia , Zhenqing Ye , Zhiquan Wang , Haiyun Gan , Chuanhe Yu <a href="about:invalid#zSoyz">Nucleic Acids Research, Volume 54, Issue 15, 27 August 2026, gkag787</a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-6214311125285710652026-09-04T17:36:57.974+01:002026-09-04T17:36:57.974+01:00<b>FANCJ and RTEL1 facilitate pre-replication complex disassembly following replisome collision</b> George Cameron ∙ Simran Negi ∙ Koichi Sato ∙ Sevim Yardimci ∙ Çağla Kaya ∙ Cameron McClymont ∙ Anoop Kumar Yadav ∙ Jana Krejci ∙ Puck Knipscheer ∙ Hana Polasek-Sedlackova∙ Hasan Yardimci <a href="https://www.cell.com/cell-reports/fulltext/S2211-1247%2826%2900938-1%20">Cell Reports, 2026; 45 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-57285362330559359972026-09-04T17:36:04.298+01:002026-09-04T17:36:04.299+01:00<b>Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation</b> Yasunori Noguchi, Almutasem Saleh, Sarah Schneider, Marina E. Ivanova, Zhuo Angel Chen, Lepakshi Ranjha, Ricardo Aramayo, Silvia Tognetti, Sarah V. Faull, Juri Rappsilber & Christian Speck <a href="https://doi.org/10.1038/s41467-026-76309-6%20">Nat Commun (2026). </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-81877868017741191612026-09-04T17:35:10.262+01:002026-09-04T17:35:10.262+01:00<b>Mechanistic diversity of clamp loading at small DNA gaps </b> Fengwei Zheng ∙ Michael E. O’Donnell ∙ Huilin Li <a href="https://www.jbc.org/article/S0021-9258%2826%2902269-6/fulltext">JBC REVIEWSArticles in Press113397August 2026 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-67928926524589620482026-09-04T17:34:20.899+01:002026-09-04T17:34:20.899+01:00<b>Pol γ possesses separate metal binding sites for polymerase and strand displacement functions </b> Noe Baruch-Torres , Joon Park , Josue Mora-Garduño , Arkanil Roy , Anupam Singh , G Andrés Cisneros , Luis G Brieba , Smita S Patel , Y Whitney Yin <a href="https://doi.org/10.1093/nar/gkag720%20%20">Nucleic Acids Research, Volume 54, Issue 14, 12 August 2026, gkag720, </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-24574456331736774862026-09-04T17:33:23.441+01:002026-09-04T17:33:23.442+01:00<b>TTF2 processes sites of incomplete DNA replication during mitosis via sister-chromatid exchanges</b> RYO FUJISAWA AND KARIM P. M. LABIB <a href="https://www.science.org/doi/10.1126/science.aeh2300%20">SCIENCE 2 Jul 2026Vol 393, Issue 6812 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-249315880964247952026-09-04T17:32:31.942+01:002026-09-04T17:32:31.942+01:00<b>RTF2 and CLASPIN localize CHK1 to the replication fork to control S-phase progression</b> CAYLA BROTON, CATHERINE L. W. MILLER, PENELOPE D. RUIZ, NICOLAS J. BLOBEL, YIBING YAO, BROOKE A. CONTI, ERNST W. SCHMID, JOHANNES C. WALTER , AND AGATA SMOGORZEWSKA <a href="https://www.science.org/doi/10.1126/sciadv.aec3174.%20">SCIENCE ADVANCES 5 Aug 2026 Vol 12, Issue 32 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-79299015243215146152026-09-04T17:31:29.244+01:002026-09-04T17:31:29.244+01:00<b>Human PIF1 clears secondary DNA structures by coupled DNA unwinding and rewinding activities </b> Akshay Jayachandran, Martin Mütze, Kostiantyn Romaniuk, Jessica J. R. Hudson, Maria Rosaria Dello Stritto, Raphaël Guérois, Ananya Acharya, Stefan Braunshier, Giordano Reginato, Issam Senoussi, Ulrich Rass, Ralf Seidel and Petr Cejka Genes & Dev. 2026. <a href="https://genesdev.cshlp.org/content/early/2026/08/08/gad.353775.126.abstract?papetoc"></a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-69017473909562170632026-09-04T17:30:36.063+01:002026-09-04T17:30:36.063+01:00<b>A CDK1 phospho-switch reprograms TRAIP to unload replisomes in mitosis</b> GEYLANI CAN , MAKSYM SHYIAN , ARCHANA KRISHNAMOORTHY , SAMREEN AHMED, YANG LIM , ALEX WU, RAPHAEL PAVANI, MANAL S. ZAHER, ANDRÉ NUSSENZWEIG MARKUS RÄSCHLE , THOMAS E. WILSON , THOMAS W. GLOVER , JOHANNES C. WALTER AND DAVID PELLMAN <a href="https://www.science.org/doi/10.1126/science.aeh1834">Science Vol 393, Issue 6812 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-32847494770462511642026-09-04T17:29:23.985+01:002026-09-04T17:29:23.985+01:00<b>CDC7 and APC/CCdh1 gate distinct routes to initiate DNA replication</b> Samsara W. Upadhya, Nalin Ratnayeke, Katherine R. Ferrick, David L. Rosenthal & Tobias Meyer <a href="https://www.nature.com/articles/s41467-026-75804-0">Nature Communications (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-31836994067675548722026-09-04T17:28:33.117+01:002026-09-04T17:28:33.118+01:00<b>Mechanisms of MCM2–7 helicase activation and initial DNA melting at near base-pair resolution</b> Christopher Weekes, Lia Willerding, Sanjay P. Khadayate, Korbinian Liebl, Audrey Mossler, Alex Montoya, Vanessa Rauthe, Mohammad M. Karimi, Martin Zacharias, Helle D. Ulrich, Christian Speck& L. Maximilian Reuter  <a href="https://www.nature.com/articles/s41467-026-75695-1%20">Nature Communications (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-33726580478403586852026-07-20T17:00:31.847+01:002026-07-20T17:00:31.847+01:00<b>A TRIM28–MCM7 regulatory axis sustains DNA replication programs in glioblastoma</b> Xiaosong Hu, Li Yang, Hongjuan Cui <a href="https://www.sciencedirect.com/science/article/pii/S0006291X26009149"> Biochemical and Biophysical Research Communications Volume 829, 3 September 2026, 154150 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-42379262638393770802026-07-20T16:59:42.942+01:002026-07-20T16:59:42.943+01:00<b>Structural and mechanistic insights into primer synthesis initiation by DNA primase</b> Pengzhi Wu, Fred F. Damberger, Johannes Zehnder, Nina Wehr, Niklas Senning, Georg Lipps, Thomas Wiegand & Frédéric H.-T. Allain <a href="https://www.nature.com/articles/s41467-026-74862-8%20">Nature Communications (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-10220182630495733092026-07-20T16:58:48.364+01:002026-07-20T16:58:48.364+01:00<b>CHD1L maintains genome integrity by facilitating okazaki fragment maturation</b> Litong Nie , Jialing Fu , Min Huang , Huimin Zhang , Tiantian Ma , Chang Yang , Siting Li , Chao Wang , Junjie Chen <a href="about:invalid#zSoyz">Nucleic Acids Research, Volume 54, Issue 12, 8 July 2026, gkag606,</a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-51424031844935486992026-07-20T16:58:03.005+01:002026-07-20T16:58:03.005+01:00<b>DNA-damage dependent interaction of Orc6 to SMARCA1 in S-phase modulates chromatin remodeling </b> Dazhen Liu , Mohit Mishra , Youyang Wang , Humayra Oishi , Aneek Mirza , Iman Fatimah Mohajir , Neha Chetlangia , Jay Sonalkar , Yo-Chuen Lin , Kannanganattu V Prasanth and Supriya G Prasanth <a href="https://doi.org/10.1093/nar/gkag582%20">Nucleic Acids Research, Volume 54, Issue 12, 8 July 2026, gkag582, </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-83176423740817284852026-07-20T16:57:01.907+01:002026-07-20T16:57:01.908+01:00<b>RECQ4 arginine methylation suppresses single-stranded DNA gap accumulation at replication forks</b> Ning Ma , Xiaohua Xu , Michael Espinoza , Chou-Wei Chang , Yukari Shiozaki , Zhigang Guo , Louis Izuagie , Binghui Shen , Yanzhong Yang , Yilun Liu <a href="about:invalid#zSoyz">Nucleic Acids Research, Volume 54, Issue 12, 8 July 2026, gkag655,</a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-25130919865412619172026-07-20T16:56:14.153+01:002026-07-20T16:56:14.153+01:00<b>Replication origin firing capacity indicates ATR inhibitor sensitivity</b> A. Lumeau, P. L. Pfuderer, J. A. Scarth, E. Maniati, M. A. Guscott, N. Shaikh, F. B. Copley, H. Gerdes, S. De Angelis, E. L. Alard, J. Wang, P. R. Cutillas, F. K. Mardakheh, M. A. Boemo, J. V. Forment & S. E. McClelland <a href="https://www.nature.com/articles/s41467-026-74588-7%20">Nature Communications (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-26371934015863065072026-07-20T16:55:22.320+01:002026-07-20T16:55:22.320+01:00<b>Spatial organization and dynamics of genome replication: from forks to foci </b> Sunil K Pradhan , Maria Arroyo , Maruthi K Pabba , Heinrich Leonhardt , M Cristina Cardoso <a href="https://doi.org/10.1093/nar/gkag550%20">Nucleic Acids Research, Volume 54, Issue 11, 24 June 2026, gkag550, </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-54303027996628207092026-07-20T16:54:14.767+01:002026-07-20T16:54:14.768+01:00<b>Distinct repair outcomes from single and convergent replication fork collapse</b> Sara C. Conwell, Khushi V. N. Patel, Savannah J. Weeks-Pollenz, Steven N. Dahmen, Matthew T. Cranford, William G. Dunphy, David T. Long, David Cortez & James M. Dewar <a href="https://www.nature.com/articles/s41594-026-01812-9?utm_source=nature_etoc&amp;utm_medium=email&amp;utm_campaign=CONR_41594_AWA1_GL_DTEC_054CI_TOC-260618&amp;utm_content=20260618">Nature Structural & Molecular Biology volume 33, pages 939–952 (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-2654847383388693302026-07-20T16:53:29.309+01:002026-07-20T16:53:29.309+01:00<b>Structure of the pre-initiation complex explains CMGE biogenesis</b> Thomas Pühringer, Berta Canal, Giacomo Palm, Agata Butryn, Emma C. Couves, Oliver Willhoft, Jacob S. Lewis, John F. X. Diffley & Alessandro Costa <a href="https://www.nature.com/articles/s41586-026-10657-7?WT.ec_id=NATURE-202606">Nature (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-14191408630444983182026-07-20T16:52:40.580+01:002026-07-20T16:52:40.580+01:00<b>TASP1-mediated cleavage of REV3L enhances the activity of DNA polymerase ζ in mammalian cells</b> Jordane Goulas, Basile Guignier, Barbara Ben Yamin, Caroline Pouvelle, Andrey Yurchenko, Emmanuelle Despras, Luciana de Oliveira, Pierre Laplante, Dorian Bochaton, Damien Plassard, Wei Yang, François-Xavier Theillet, Xavier Veaute, Richard D. Wood, Sergey Nikolaev, Agnès M. Cordonnier & Patricia L. Kannouche  <a href="https://www.nature.com/articles/s41467-026-74271-x%20">Nature Communications (2026) </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-44042978562302975252026-07-20T16:51:42.529+01:002026-07-20T16:51:42.530+01:00<b>ATP is dispensable for E. coli DNA replication and eukaryotic helicase activity</b> Richard R. Spinks, Aleksa Lakic, Celine Kelso, Slobodan Jergic, Olga Yurieva, Zhi-Qiang Xu, Michael E. O’Donnell, Nicholas E. Dixon, Antoine M. van Oijen, Jacob S. Lewis & Lisanne M. Spenkelink  <a href="https://doi.org/10.1038/s41467-026-73893-5">Nat Commun (2026). </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-1042803597825227012026-07-20T16:50:51.838+01:002026-07-20T16:50:51.839+01:00<b>Replication origin flexibility: a tool to mitigate the hazards of excess replication</b> Haiqing Fu ∙ Christophe E. Redon ∙ Hannah M. Brenner ∙ Michael R. Ack ∙ Mirit I. Aladjem <a href="https://www.cell.com/trends/genetics/fulltext/S0168-9525%2826%2900057-0?dgcid=raven_jbs_etoc_email">Trends in Genetics, 2026; 42, 510-523 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0tag:blogger.com,1999:blog-270610774457782174.post-73164904894172800742026-07-20T16:50:00.110+01:002026-07-20T16:50:00.111+01:00<b>Primase subunit 2 regulates the proliferation and apoptosis of gastric cancer cells via MCM7/CDK4 and Bax/Bcl-2 pathways</b> Biochimica et Biophysica Acta (BBA) - General Subjects <a href="https://www.sciencedirect.com/science/article/pii/S0304416526000474">Volume 1870, Issue 7, July 2026, 130947 </a> Sue Cotterillhttp://www.blogger.com/profile/02135935985771594471noreply@blogger.com0