Noc3

 

Suggested to have a role in initiation (1)

 

 

 

 

Synonyms

 

Molecular weight

76 kDa (Sc)

Biochemical properties

 

Motifs

•bHLH

 •NLS

Protein interactions

Sc

•ORC, Mcm2-7 (1)

•Mcm5 (1)

 

Modifications

 

Cellular location and expression

Sc

•Binds to ori (ARS) DNA sequence all through the cell cycle

 

 

Other comments

•DNA replication function only reported in Sc

 

•Needs ORC for chromatin association

 

•Previously isolated as tRNA and pre ribosome maturation factor

 

•Not required in vitro for preRC formation (2).

 

 

Revised by

 

Last edited

13 Apr 08

 

1.    Zhang,Y., Yu,Z., Fu,X. and Liang,C. (2002) Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Cell 109, 849-860.

2.    Kawasaki,Y., Kim,H.D., Kojima,A., Seki,T. and Sugino,A. (2006) Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro. Genes Cells 11, 745-756.