Mcm9

 

Related to Mcm2-7 family but apparently in distinct complex and much less abundant. Suggested involvement in initiation step of DNA replication. Only present in vertebrates.

 

Orthologues

 

Molecular weight

 

Biochemical properties

 

Xl

• Possible role in mcm 2-8 loading/ controlling cdt1:geminin ratio (1)

Motifs

Xl

• n terminus has high homologyto MCM 2-8 (1)

Interactions

Xl

• cdt1 and geminin ( low levels)  (1)

 

Modifications

 

Structure

 

Cellular location and expression

 

Mammals

 

 

Other comments

 

Revised by

 

Last edited

13 July 09

 

 

1.    Lutzmann,M. and Mechali,M. (2008) MCM9 binds Cdt1 and is required for the assembly of prereplication complexes. Mol Cell 31, 190-200.