Cdc24

 

Required for elongation step of DNA replication. Linked to DNA polymerase delta function and Okazaki fragment processing.

 

Synonyms
Molecular weight	58.0 kDa
Biochemical properties
Motifs
Protein interactions	Sp •Dna2 (1) •PCNA (PCNA interaction domain) and rfc (1) • RFC (1) • mcm2 4 10 (1) •ScDna2 (2) •Pol3, Cdc27 (pol delta subunits (3) •ck1 (1) •pole ( no effect d) (1) •Pfh1 (4)
Modifications
Structure
Cellular location and expression
Other comments
Revised by
Last edited	15 April 08

 

 

1.    Tanaka,H., Tanaka,K., Murakami,H. and Okayama,H. (1999) Fission yeast cdc24 is a replication factor C- and proliferating cell nuclear antigen-interacting factor essential for S-phase completion. Mol Cell Biol 19, 1038-1048.

2.    Gould,K.L., Burns,C.G., Feoktistova,A., Hu,C.P., Pasion,S.G. and Forsburg,S.L. (1998) Fission yeast cdc24(+) encodes a novel replication factor required for chromosome integrity. Genetics 149, 1221-1233.

3.    Tanaka,H., Ryu,G.H., Seo,Y.S. and MacNeill,S.A. (2004) Genetics of lagging strand DNA synthesis and maturation in fission yeast: suppression analysis links the Dna2-Cdc24 complex to DNA polymerase delta. Nucleic Acids Res32, 6367-6377.

4.    Tanaka,H., Ryu,G.H., Seo,Y.S., Tanaka,K., Okayama,H., MacNeill,S.A. and Yuasa,Y. (2002) The fission yeast pfh1(+) gene encodes an essential 5' to 3' DNA helicase required for the completion of S-phase. Nucleic Acids Res 30, 4728-4739.